Low Brain pH may lead to Panic Attacks, Schizophrenia and Bipolar Disease

Dr. Shapira Cluster Headache, Depression and Chronic Pain, SPG Block, SPG Block Anxiety, SPG Block Migraine, Sphenopalatine Ganglion Blocks, Uncategorized 0 Comments

SPG Blocks are often extremely successful for treating Panic Attacks as well as Headaches, Orofacial Pain,Trigeminal Neuralgia and Migraines. Neuromuscular Dentistry has been shown to increase blood flow to the brain.

Can Brain pH be addressed with Hyperbaric Oxygen to treat Panic Attacks, Bipolar and Schizophrenic disease?

I work with Dr Steven Best at the Neuroscience center in who utilizes SPECT scans diagnostically and Hyperbaric Oxygen Treatment. http://www.neurosciencechicago.com/

The SPECT scan frequently show areas that are hypoxic (low oxygen) and likely have low pH from CO@ build up.

Hyperbaric oxygen can treat hypoxic areas identified on SPECT scan that I recently saw in a physician and patient who was treated with SPG Blocks, and Hyperbaric Oxygen.

Is Hyperbaric Oxygen a possible cure or treatment of these disorders or is the low pH secondary to the disease. There is little risk to Hyperbaric oxygen and many possible benefits.

The abstract and link to full article below:

Neuropsychopharmacology advance online publication 6 September 2017; doi: 10.1038/npp.2017.167

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Hideo Hagihara1, Vibeke S Catts2,3, Yuta Katayama4, Hirotaka Shoji1, Tsuyoshi Takagi5,6, Freesia L Huang7, Akito Nakao1, Yasuo Mori8, Kuo-Ping Huang7, Shunsuke Ishii6, Isabella A Graef9, Keiichi I Nakayama4, Cynthia Shannon Weickert2,3 and Tsuyoshi Miyakawa1

1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
2Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, Australia
3School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
4Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
5Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan
6RIKEN Tsukuba Institute, Tsukuba, Japan
7Program of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, USA
8Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan
9Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
Correspondence: Dr T Miyakawa, Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan, Tel: +81 562 93 9376, Fax: +81 562 92 5382, E-mail: miyakawa@fujita-hu.ac.jp

Received 4 May 2017; Revised 14 July 2017; Accepted 1 August 2017
Accepted article preview online 4 August 2017; Advance online publication 6 September 2017

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Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased brain pH relative to those of healthy controls upon postmortem examination, it remains controversial whether this finding reflects a primary feature of the diseases or is a result of confounding factors such as medication and agonal state. To date, systematic investigation of brain pH has not been undertaken using animal models that can be studied without confounds inherent in human studies. In the present study, we first reevaluated the pH of the postmortem brains of patients with schizophrenia and bipolar disorder by conducting a meta-analysis of existing data sets from 10 studies. We then measured pH, lactate levels, and related metabolite levels in brain homogenates from five neurodevelopmental mouse models of psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorder. All mice were drug naive with the same agonal state, postmortem interval, and age within each strain. Our meta-analysis revealed that brain pH was significantly lower in patients with schizophrenia and bipolar disorder than in control participants, even when a few potential confounding factors (postmortem interval, age, and history of antipsychotic use) were considered. In animal experiments, we observed significantly lower pH and higher lactate levels in the brains of model mice relative to controls, as well as a significant negative correlation between pH and lactate levels. Our findings suggest that lower pH associated with increased lactate levels is not a mere artifact, but rather implicated in the underlying pathophysiology of schizophrenia and bipolar disorder.

Link to full article:

Chicago TMJ Disorders: Reprinted from 24/7 Press Release

Dr. Shapira Causes of TMJ, Chicago, Clicking & Popping, Uncategorized 0 Comments

Chicago TMJ Disorders: TMJ, “The Great Imposter” Amazing Patient Testimonials Videos Describe How Physiologic Dental Treatment Can Eliminate Headaches, Migraines, Facial Pain and Neck Pain.

Improved Quality of Life: These are actual patient testimonial videos of outstanding improvements in quality of life with Physiologic Treatment of TMJ and Pain Disorders. Hear about recovery from a patient a Mayo Clinic MD told her was hopeless.

Headaches and Migraines affect 25% of US households. At least 10% of the population suffers from chronic headaches. Dr Ira Shapira, a long time Highland Park resident founded I Hate Headaches.org to to help patients suffering from chronic migraines, sinus headaches, chronic daily headaches, tension headaches and TMJ headaches. Over 95% of all headache patients have Trigeminal Nerve mediated headaches. His premiere website www.ihateheadaches.org has helped thousands of patients understand how the Trigeminal Nerve and the structures it innervates are responsible for the majority of all headaches.

Many patients think that TMJ (TMD) disorders are only treated with splints. Dr Ira Shapira utilizes a multifaceted approach to giving patients quick and lasting relief from their chronic pain. He utilizes Diagnostic Physiologic Orthotics and has over 30 years experience in Physiologic Dentistry. He trained with Barney Jankelson the founder of this field and with Bob Jankelson, his son. In addition to utilizing Physiologic Dentistry he is one of only a handful of practitioners to utilize SPG Blocks (Sphenopalatine Ganglion Blocks), Trigger Point Injections and Spray and Stretch techniques to treat Myofascial Pain and Muscle pain from Fibromyalgia. He trained with Dr Janet Travell who wrote the book Myofacial Pain and Dysfunction: A Trigger Point Manual.

This link leads to a YouTube Channel of Think Better Life Patient Testimonial videos.

Everyone with chronic TMJ pain, migraines, neck pain or facial pain should view these videos.

The Website for Dr Shapira’s new Highland Park office is www.thinkbetterlife.com.

The new office is a 1 minute walk from the Fort Sheridan Metra Station for easy accessibility for Chicago patients who depend on public transportation.

According to the Migraine Research Foundation website:

“Migraine is an extraordinarily common disease that affects 36 million men, women and children in the United States. Almost everyone either knows someone who has suffered from migraine, or has struggled with migraine themselves. Nearly 1 in 4 U.S. households includes someone with migraine. Amazingly, over 10% of the population – including children – suffers from migraine. That’s more than diabetes and asthma combined! About 18% of American women and 6% of men suffer from migraine. Migraine is most common during the peak productive years, between the ages of 25 and 55.”

TMJ Disorders have been dubbed “The Great Imposter” because the majority of patients are misdiagnosed or only partially diagnosed by the medical community. The Trigeminal Nerve is frequently called “The Dentists Nerve” because it goes to the teeth, periodontal ligaments,, the sinuses, the tongue, the jaw joints and jaw muscles, as well as the tongue, the tensor of the ear drum, the muscle that opens and closes the eustacian tube and a major contribution to the autonomic nervous system. The Trigeminal Nerve also controls the blood flow to the anterior two thirds of the meninges of the brain, or in simple terms the Trigeminal nerve determines whether you will have migraines. The Trigeminal Nerves or Fifth Cranial Nerves is also the single largest contributor to Chronic Headaches and Migraine. Physiologic Dentistry is extremely effective in eliminating and treating migraines specifically because of the trigeminal nerve connection. Physiologic Dentistry is specifically directed towards eliminating trigeminal nerve nociception or painful input to the central nervous system.

What the majority of the medical community does not know is that TMJ or TemporoMandibular Disorders can have effects on almost every system in the body. The NHLBI or National Heart Lung and Blood Institute of the NIH published a report entitled CARDIOVASCULAR AND SLEEP-RELATED CONSEQUENCES OF TEMPOROMANDIBULAR DISORDERS that looked at the far reaching effects of TMJ disorders. The report recognizes the importance of “The masticatory apparatus is not only involved in chewing and swallowing but also in other critical tasks, including breathing and talking.”

The NIH report also state, “TMD has been used to characterize a wide range of conditions diversely presented as pain in the face or jaw joint area, masticatory muscle pain, headaches, earaches, dizziness, limited mouth opening due to soft or hard tissue obstruction, TMJ clicking or popping sounds, excessive tooth wear and other complaints.”

The report shows that 12% of the population suffers from TMD similar to the number suffering chronic headaches and migraines. The report has a major section on “The Craniofacial Complex and its Impact on Control of Upper Airway Resistance and Cardiopulmonary Function” The report covers the pathophysiology of sleep apnea which is implicated in morning headaches, fibromyalgia and Myofascial Pain and Dysfunction. It is now well established that oral appliances are a first line approach to treatment of sleep apnea and snoring for mild to moderate sleep apnea and an alternative to CPAP for severe sleep apnea.

The Autonomic portion of the Trigeminal Nerve is a key cause and cure for migraines and headaches. This is because of its innervation of the meninges of the brain and its control of blood flow to the brain. The SPG Block or Sphenopalatine Ganglion Block is sometimes considered a miracle cure for migranes. The popular book “Miracles on Park Ave” dealt specifically with the high efficacy of SPG Blocks in treating pain. The new MiRx protocol (http://www.mirxprotocol.com/) that has been show effective for preventing and treating migraines is actually just a different method of utilizing the SPG Block. Dr Shapira has been teaching utilization of the SPG Block to dentists and other healthcare professionals for many years.

Learn more about SPG Blocks @ http://chicago-headaches.blogspot.com and at www.thinkbetterlife.com.

The Mayo Clinic has also clearly stated the importance of the Trigeminal Nerve is headaches and Migraines “Although much about headaches still isn’t understood, researchers think migraines may be caused by functional changes in the Trigeminal Nerve system, a major pain pathway in your nervous system, and by imbalances in brain chemicals, including serotonin, which plays a regulatory role for pain messages going through this pathway.”

Mayo clinic also states, “During a headache, serotonin levels drop. Researchers believe this causes the Trigeminal Nerveto release substances called neuropeptides, which travel to your brain’s outer covering (meninges). There they cause blood vessels to become dilated and inflamed. The result is headache pain.”

These meninges are the Trigeminally innervated meninges discussed earlier and the serotonin and neuropeptides are the chemicals produced by nerve cells. These same chemicals are involved in TMJ, TMD and Migraines. The Trigeminal Nerve always utilizes these neurotransmitters not just for migraines.

Dr Shapira spent years doing research into sleep apnea and its connection to jaw position. His early research was done as a Visiting Assistant Professor in the 1980’s at Rush Medical School in The Sleep Disorder clinic. He worked closely with Dr Rosalind Cartwright the acknowledged Mother of Dental Sleep Medicine. Dr Cartwright recruited Dr Shapira to return to Rush as an Asst Professor in the 1990’s till early this century.

The connections between impaired nasopharyngeal breathing and development of ADD and ADHD in children was the topic of a recent lecture Dr Shapira gave in Buenos Aires, Argentina. The development of chronic TMJ disorders, headaches, migraines and postural distortions were all discussed at his lecture to members of ICCMO, The International College of CranioMandibular Orthopedics of which Dr Shapira is a Fellow and Secretary. Dr Shapira is a representative from ICCMO to the American Alliance of TMD Organizations and current Chair of the Alliance of TMD Organizations.

In the 1990’s Dr Shapira was a star lecturer for the A4M, The American Academy of Anti-Aging Medicine where he presented his work on the effect of TMJ disorders across ones lifetime. Premature aging and loss of memory and even dementia and Altzheimers disease are part of the same ongoing problem. Sleep Apnea and snoring are types of TMJ disorders according to the National Heart Lung and Blood Institute of the NIH in their report: Cardiovascular and Sleep Related Consequences of Temporomandibular Disorders.

Dr Shapira has been utilizing a multifaceted approach toward relieving chronic pain associated with TMJ disorders for over 30 years and is now bringing his expertise to the North Shore Communities of Chicago. He created www.IHATECPAP.com which addressed Sleep Apnea and snoring and utilizing oral appliances to treat these problems. He also created www.ihateheadaches.org that focuses on many types of headaches and the role of Physiologic Dentistry in providing relief of these problems.

The DNA Appliance is offering a possible cure for sleep apnea and TMJ disorders by growing the jaws utilizing Epigenetic Orthodontics. Until recently it was believed these changes could only be accomplished through extensive surgical procedures.

Dr Shapira has also studied Cranial Suture Release techniques and Chirodontics. He inroduced these concepts to a Chiropracter who is his friend and colleague, Dr Mark Freund . Dr Freund has embraced these concepts in totality and has become an expert in these techniques through immersive studying both in the US and Internationally. His primary office is in Lindenhurst but he also sees Cranial patients in Gurnee in Dr Shapira’s office www.delanydentalcare.com.

Dr Freund will be treating patients in Dr Shapira’s Highland Park office. These techniques treat not only TMJ Dysfunction but also postural distortion such as forward head posture that leads to headaches and neck pain. These postural distortions can have negative effects throughout the entire body.

The NIH just reported over 25 million Americans suffer chronic pain or 11.2% of all Americans. See The Washington Post Story. http://www.washingtonpost.com/news/to-your-health/wp/2015/08/11/nih-m … onic-pain/

Dr Ira L Shapira created the I HATE CPAP (www.ihatecpap.com) and I HATE HEADACHE (www.ihateheadaches.org) websites to help patients find help with these difficult medical disorders that medicine can frequently not treat adequately without a dental collaboration. Dr Shapira did research in the 1980’s as a visiting assistant professor at Rush Medical School where he worked with Rosalind Cartwright PhD who is primarily responsible for the entire field of Dental Sleep Medicine. He also studied with Dr Barney Jankelson who created the initial concepts that physiologic dentistry still uses today and created a company Myotronics that is the leading manufacturer of instrumentation used by Physiologic Dentistry.

Dr Shapira is the current Chair, Alliance of TMD Organizations

Dr Shapira is a Diplomate of The American Board of Dental Sleep Medicine, a Diplomate of the American Academy of Pain Management, and a Fellow of the International College of CranioMandibular Orthopedics (ICCMO). He is a former national and International Regent of ICCMO, its current Secretary and the representative to the Alliance of TMD organizations or the TMD ALLIANCE has a general dental practice (http://www.delanydentalcare.com) in Gurnee, Il and has recently started Chicagoland Dental Sleep Medicine Associates with offices in Vernon Hills and Highland Park. Patients in Northern Illinois or southern Wisconsin can contact Dr Shapira by phone toll free at 1-8-NO-PAP-MASK OR 1-800-TM-JOINT or thru his websites at http://www.ihateheadaches.org or http://www.chicagoland.ihatecpap.com.

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Read more Press Releases from Ira Shapira:
Chicago: ADD & ADHD Prevention and Treatment: Sleep Disordered Breathing in Young Children Is a Primary Cause of ADD, ADHD and Bed-Wetting
Can Dentistry Prevent ADD and ADHD and Cure Bed-Wetting? Learn How The Perfect Start System Can Improve Your Child’s Airway. Correction Of Pediatric Sleep Disordered Breathing Is The Key
Physiologic Dentistry: Migraine,Chronic Daily Headache and TMJ Treatment. Find A Physiologic Dentist at ICCMO,The International College of CranioMandibular Orthopedics
Gurnee Dentist is New Chair of The American Alliance of TMD Organizations. Dr Ira L Shapira’s Practice Focuses on TMJ Disorders, Sleep Apnea, Snoring, Chronic Daily Headaches and Migraines
Highland Park Dentist is New Chair of The American Alliance of TMD Organizations. New Highland Park Office Focuses on TMJ Disorders, Sleep Apnea, Snoring, Chronic Daily Headaches and Migraines…

Why Do My Holidays Get Worse On The Holidays

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It is very common for us to see new TMJ and Headache Patients during the holiday season. If the problem is relate to the TMJ, the teeth , the jaw muscles why does this happen?

There are many things associated with the holidays that can exacerbate your pain. First, our schedules and life style changes, we eat different, our sleep schedule changes and we often spend great deal of time with families. Very often old conflicts that have never been resolved rise to the surface. Chronic trigger points in muscles are often connected to emotional memories in our brain.

Sometimes when we do trigger point injections old repressed memories are remembered, often coming with the full emotional effect of when the problems initiated. The same happens when we stir up old memories and emotions and they activate old trigger points.

Trigger Points can be active or latent. The active trigger points cause referred pain. Emotional conflict or upset can turn on our latent trigger points making them active. Lack of sleep, poor nutrition, muscle overuse and allergies are other factors that can make latent trigger points become active.

Many people will clench or grind their teeth when under high stress. Like it or not being with family can be stressful. The clenching and grinding can push us into a state of pain while previously our resistance kept the pain below threshold levels.…

What is TMJ?

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What is TMJ? Learn more about it!


Everyone experiences occasional headaches, shoulder pain, or sore neck. Most of the time we can dismiss the cause as nothing more than stress or our busy lives, but, when pain becomes a daily occurrence or is accompanied by other symptoms, there could be something more going on.

If you are suffering from undiagnosed, chronic pain, TMJ may be the reason. But what is TMJ, and why does it cause pain?

How does your TMJ work?

TMJ is an abbreviated term for the temporomandibular joint also known as your jaw joint. Other abbreviations; TMD for Temporomandibular Disorder and TMJD for Temporomandibular Joint Disorder, are also accepted and used interchangeably  to refer to the pain, disorder or dysfunction of this joint and other affected areas surrounding it.

Like all of the wonderfully complex parts of our bodies, the temporomandibular joint is designed for smooth, continuous and pain-free operation. These two essential joints work in unison to allow you to:

  • bite
  • speak
  • chew
  • sing
  • yawn
  • laugh
  • talk

In fact, for your jaw to do everything you need it to, it must be able to open close, move forward and back and from side to side.

The bones of your joints do not work alone. To move, each of your ball and socket jaw joints are cushioned by a disc and surrounded by the muscles, ligaments and nerves that make them work.

What causes jaw problems?

While TMJ causes are not always clear, they are often be related to specific events or life changes, including:

  • uneven dentistry
  • direct injury to the temporomandibular joint
  • ongoing stress resulting in bruxism and clenching of the jaw
  • shifting or missing teeth
  • a misaligned jaw or underdeveloped jaw due to genetics or childhood breathing problems
  • arthritis
  • sleep disorders, especially sleep disordered breathing

Where does the pain come from?

Since the TM joint consists of so many interdependent parts, if even one piece is out of commission, stressed or damaged in some way, the rest of the connecting parts are affected. This includes the part of our nervous system that is responsible for providing input to the brain for as much as 40 percent of the human head and face.

The nerve, specifically called the trigeminal nerve is of great interest to the physiologic dentist evaluating and treating TMJ disorders. As the name implies, there are three branches to this nerve, and they are connected with many of the functions of the TM joint, including:

  • Routine chewing functions of the upper and lower jaw
  • Swallowing
  • Breathing
  • Talking
  • Kissing
  • Eyes
  • Ears
  • Sinuses
  • Teeth

Even though TMJ pain directly communicates through the trigeminal nerve structures, it may also result in referred pain to certain locations in the head and neck.  Almost 100% of all headaches  and migraines, as well as sinus pain are mediated primarily by the trigeminal nerve.  Symptoms of referred pain may include the following symptoms:

  • Frequent morning headaches or migraines
  • Grinding, clicking or popping noise in the TM joints
  • Dizziness
  • Neck, shoulder or back pain
  • Tinnitus

Learn more about TMJ

DentistTMJ is a complex disorder. Effective treatment depends on an accurate diagnosis.

If you would like to find out if TMJ is at the root of your chronic pain, take our TMJ questionnaire or, better yet, come in for a consultation.