SPG Blocks are often extremely successful for treating Panic Attacks as well as Headaches, Orofacial Pain,Trigeminal Neuralgia and Migraines. Neuromuscular Dentistry has been shown to increase blood flow to the brain.
Can Brain pH be addressed with Hyperbaric Oxygen to treat Panic Attacks, Bipolar and Schizophrenic disease?
I work with Dr Steven Best at the Neuroscience center in who utilizes SPECT scans diagnostically and Hyperbaric Oxygen Treatment. http://www.neurosciencechicago.com/
The SPECT scan frequently show areas that are hypoxic (low oxygen) and likely have low pH from CO@ build up.
Hyperbaric oxygen can treat hypoxic areas identified on SPECT scan that I recently saw in a physician and patient who was treated with SPG Blocks, and Hyperbaric Oxygen.
Is Hyperbaric Oxygen a possible cure or treatment of these disorders or is the low pH secondary to the disease. There is little risk to Hyperbaric oxygen and many possible benefits.
The abstract and link to full article below:
Neuropsychopharmacology advance online publication 6 September 2017; doi: 10.1038/npp.2017.167
Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders
Hideo Hagihara1, Vibeke S Catts2,3, Yuta Katayama4, Hirotaka Shoji1, Tsuyoshi Takagi5,6, Freesia L Huang7, Akito Nakao1, Yasuo Mori8, Kuo-Ping Huang7, Shunsuke Ishii6, Isabella A Graef9, Keiichi I Nakayama4, Cynthia Shannon Weickert2,3 and Tsuyoshi Miyakawa1
1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
2Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, Australia
3School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
4Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
5Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan
6RIKEN Tsukuba Institute, Tsukuba, Japan
7Program of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, USA
8Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan
9Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
Correspondence: Dr T Miyakawa, Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan, Tel: +81 562 93 9376, Fax: +81 562 92 5382, E-mail: [email protected]
Received 4 May 2017; Revised 14 July 2017; Accepted 1 August 2017
Accepted article preview online 4 August 2017; Advance online publication 6 September 2017
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Abstract
Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased brain pH relative to those of healthy controls upon postmortem examination, it remains controversial whether this finding reflects a primary feature of the diseases or is a result of confounding factors such as medication and agonal state. To date, systematic investigation of brain pH has not been undertaken using animal models that can be studied without confounds inherent in human studies. In the present study, we first reevaluated the pH of the postmortem brains of patients with schizophrenia and bipolar disorder by conducting a meta-analysis of existing data sets from 10 studies. We then measured pH, lactate levels, and related metabolite levels in brain homogenates from five neurodevelopmental mouse models of psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorder. All mice were drug naive with the same agonal state, postmortem interval, and age within each strain. Our meta-analysis revealed that brain pH was significantly lower in patients with schizophrenia and bipolar disorder than in control participants, even when a few potential confounding factors (postmortem interval, age, and history of antipsychotic use) were considered. In animal experiments, we observed significantly lower pH and higher lactate levels in the brains of model mice relative to controls, as well as a significant negative correlation between pH and lactate levels. Our findings suggest that lower pH associated with increased lactate levels is not a mere artifact, but rather implicated in the underlying pathophysiology of schizophrenia and bipolar disorder.
Link to full article:
http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2017167a.html
